The Centers for Disease Control and Prevention (CDC) has now confirmed 6 deaths, possibly linked to e-cigarette use.
The CDC said Friday that the number of possible cases of severe respiratory illnesses among people who vaped nicotine or cannabis-related products has more than doubled, to 450 in 33 states.
This investigation is ongoing and has not identified a cause, but all reported cases have a history of using e-cigarette products.
As of August 27, 215 possible cases of severe pulmonary disease associated with the use of electronic cigarette, or e-cigarette, products, have been reported by 25 states and additional pulmonary illnesses are under investigation.
These are preliminary case counts based on initial reports. A new standardized case definition was released by the CDC on August 25.
Additional reports of pulmonary illness are being investigated by states to determine whether those illnesses are related to e-cigarette product use. These numbers are likely to change over time.
The available evidence does not currently suggest that an infectious disease is the cause of the illnesses.
The investigation has not identified any specific substance or e-cigarette product that is linked to all cases.
Many patients report using e-cigarette products with liquids that contain cannabinoid products, such as tetrahydrocannabinol (THC).
These investigations are ongoing and the CDC will provide updates when more information is available.
At least 10.8 million adults are estimated to use e-cigarette products in the U.S., according to 2016 data reported in the Annals of Internal Medicine. Of those, 15 percent said they had never smoked cigarettes.
E-cigarettes are the most common way U.S. teens use tobacco, according to a 2018 study by the Department of Health and Human Services.
The FDA encourages people to submit reports of illnesses that may be related to this disease to FDA Safety Reporting Portal at www.safetyreporting.hhs.gov.